He married Ann Dickinson Hinton on September 29, 1832, at Wabash Camping Grounds in Giles County, Virginia. They had eight children in 18 years: Margaret Ann, John, James Harrison, Andrew Jackson, Mary Emmaline, Allen Meador, Elizabeth, and Robert Greenlee.
Per death records, he died on November 30, 1853, in Mercer, West Virginia, at the age of 45.
Source: History of Mercer County 1984
John died when he was thrown from his horse while returning from the grist mill. Their home was near the mouth of Lick Creek in Giles County, Virginia, which is now part of Summers County, West Virginia.